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Neutron diffraction studies of Escherichia coli dihydrofolate reductase complexed with methotrexate
Hydrogen atoms play a central role in many biochemical processes yet are difficult to visualize by x-ray crystallography. Spallation neutron sources provide a new arena for protein crystallography with TOF measurements enhancing data collection efficiency and allowing hydrogen atoms to be located in...
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| Hauptverfasser: | , , , , , , |
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| Format: | Artigo |
| Sprache: | Inglês |
| Veröffentlicht: |
National Academy of Sciences
2006
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| Schlagworte: | |
| Online Zugang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC1664550/ https://ncbi.nlm.nih.gov/pubmed/17130456 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.0604977103 |
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