Toward resolving the catalytic mechanism of dihydrofolate reductase using neutron and ultrahigh-resolution X-ray crystallography

Dihydrofolate reductase (DHFR) catalyzes the NADPH-dependent reduction of dihydrofolate (DHF) to tetrahydrofolate (THF). An important step in the mechanism involves proton donation to the N5 atom of DHF. The inability to determine the protonation states of active site residues and substrate has led...

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Bibliografiset tiedot
Julkaisussa:Proc Natl Acad Sci U S A
Päätekijät: Wan, Qun, Bennett, Brad C., Wilson, Mark A., Kovalevsky, Andrey, Langan, Paul, Howell, Elizabeth E., Dealwis, Chris
Aineistotyyppi: Artigo
Kieli:Inglês
Julkaistu: National Academy of Sciences 2014
Aiheet:
Biological Sciences
Linkit:https://ncbi.nlm.nih.gov/pmc/articles/PMC4280638/
https://ncbi.nlm.nih.gov/pubmed/25453083
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1415856111
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