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Neutron diffraction studies of Escherichia coli dihydrofolate reductase complexed with methotrexate

Hydrogen atoms play a central role in many biochemical processes yet are difficult to visualize by x-ray crystallography. Spallation neutron sources provide a new arena for protein crystallography with TOF measurements enhancing data collection efficiency and allowing hydrogen atoms to be located in...

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Hlavní autoři: Bennett, Brad, Langan, Paul, Coates, Leighton, Mustyakimov, Marat, Schoenborn, Benno, Howell, Elizabeth E., Dealwis, Chris
Médium: Artigo
Jazyk:Inglês
Vydáno: National Academy of Sciences 2006
Témata:
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC1664550/
https://ncbi.nlm.nih.gov/pubmed/17130456
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.0604977103
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