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Ubiquitin-mediated sequestration of normal cellular proteins into polyglutamine aggregates

A hallmark of most neurodegenerative diseases, including those caused by polyglutamine expansion, is the formation of ubiquitin (Ub)-positive protein aggregates in affected neurons. This finding suggests that the Ub system may be involved in common mechanisms underlying these otherwise unrelated dis...

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Udgivet i:Proc Natl Acad Sci U S A
Principais autores: Donaldson, Kathryn M., Li, Wei, Ching, Keith A., Batalov, Serge, Tsai, Chih-Cheng, Joazeiro, Claudio A. P.
Format: Artigo
Sprog:Inglês
Udgivet: National Academy of Sciences 2003
Fag:
Biological Sciences
Online adgang:https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC166409/
https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/12857950/
https://ncbi.nlm.nih.govhttps://doi.org/10.1073/pnas.1530212100
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