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Natural selection of more designable folds: A mechanism for thermophilic adaptation

An open question of great interest in biophysics is whether variations in structure cause protein folds to differ in the number of amino acid sequences that can fold to them stably, i.e., in their designability. Recently, we have shown that a novel quantitative measure of a fold's tertiary topology,...

Πλήρης περιγραφή

Αποθηκεύτηκε σε:
Λεπτομέρειες βιβλιογραφικής εγγραφής
Εκδόθηκε σε:Proc Natl Acad Sci U S A
Κύριοι συγγραφείς: England, Jeremy L., Shakhnovich, Boris E., Shakhnovich, Eugene I.
Μορφή: Artigo
Γλώσσα:Inglês
Έκδοση: National Academy of Sciences 2003
Θέματα:
Διαθέσιμο Online:https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC166380/
https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/12843403/
https://ncbi.nlm.nih.govhttps://doi.org/10.1073/pnas.1530713100
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