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Natural selection of more designable folds: A mechanism for thermophilic adaptation

An open question of great interest in biophysics is whether variations in structure cause protein folds to differ in the number of amino acid sequences that can fold to them stably, i.e., in their designability. Recently, we have shown that a novel quantitative measure of a fold's tertiary topo...

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Detalles Bibliográficos
Main Authors: England, Jeremy L., Shakhnovich, Boris E., Shakhnovich, Eugene I.
Formato: Artigo
Idioma:Inglês
Publicado: National Academy of Sciences 2003
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Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC166380/
https://ncbi.nlm.nih.gov/pubmed/12843403
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1530713100
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