Polysialic Acid Directs Tumor Cell Growth by Controlling Heterophilic Neural Cell Adhesion Molecule Interactions

Polysialic acid (PSA), a carbohydrate polymer attached to the neural cell adhesion molecule (NCAM), promotes neural plasticity and tumor malignancy, but its mode of action is controversial. Here we establish that PSA controls tumor cell growth and differentiation by interfering with NCAM signaling a...

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Main Authors: Seidenfaden, Ralph, Krauter, Andrea, Schertzinger, Frank, Gerardy-Schahn, Rita, Hildebrandt, Herbert
Formato: Artigo
Idioma:Inglês
Publicado: American Society for Microbiology 2003
Assuntos:
Cell Growth and Development
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC166353/
https://ncbi.nlm.nih.gov/pubmed/12897159
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/MCB.23.16.5908-5918.2003
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