Physical and Functional Interaction between DNA Ligase IIIα and Poly(ADP-Ribose) Polymerase 1 in DNA Single-Strand Break Repair

The repair of DNA single-strand breaks in mammalian cells is mediated by poly(ADP-ribose) polymerase 1 (PARP-1), DNA ligase IIIα, and XRCC1. Since these proteins are not found in lower eukaryotes, this DNA repair pathway plays a unique role in maintaining genome stability in more complex organisms....

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Bibliographic Details
Main Authors: Leppard, John B., Dong, Zhiwan, Mackey, Zachary B., Tomkinson, Alan E.
Format: Artigo
Language:Inglês
Published: American Society for Microbiology 2003
Subjects:
DNA Dynamics and Chromosome Structure
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC166336/
https://ncbi.nlm.nih.gov/pubmed/12897160
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/MCB.23.16.5919-5927.2003
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