Adenosine mediates IL-13–induced inflammation and remodeling in the lung and interacts in an IL-13–adenosine amplification pathway

IL-13 is an important mediator of inflammation and remodeling. We hypothesized that adenosine accumulation, alterations in adenosine receptors, and adenosine–IL-13 autoinduction are critical events in IL-13–induced pathologies. To test this, we characterized the effects of IL-13 overexpression on th...

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Main Authors: Blackburn, Michael R., Lee, Chun G., Young, Hays W.J., Zhu, Zhou, Chunn, Janci L., Kang, Min Jong, Banerjee, Suman K., Elias, Jack A.
Format: Artigo
Sprog:Inglês
Udgivet: American Society for Clinical Investigation 2003
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Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC166289/
https://ncbi.nlm.nih.gov/pubmed/12897202
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1172/JCI200316815
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