SLC5A8, a sodium transporter, is a tumor suppressor gene silenced by methylation in human colon aberrant crypt foci and cancers

We identify a gene, SLC5A8, and show it is a candidate tumor suppressor gene whose silencing by aberrant methylation is a common and early event in human colon neoplasia. Aberrant DNA methylation has been implicated as a component of an epigenetic mechanism that silences genes in human cancers. Usin...

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Hauptverfasser: Li, Hui, Myeroff, Lois, Smiraglia, Dominic, Romero, Michael F., Pretlow, Theresa P., Kasturi, Lakshmi, Lutterbaugh, James, Rerko, Ronald M., Casey, Graham, Issa, Jean-Pierre, Willis, Joseph, Willson, James K. V., Plass, Christoph, Markowitz, Sanford D.
Format: Artigo
Sprache:Inglês
Veröffentlicht: National Academy of Sciences 2003
Schlagworte:
Biological Sciences
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC166243/
https://ncbi.nlm.nih.gov/pubmed/12829793
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1430846100
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