Cefotaxime Acts Synergistically with Levofloxacin in Experimental Meningitis Due to Penicillin-Resistant Pneumococci and Prevents Selection of Levofloxacin-Resistant Mutants In Vitro

Cefotaxime, given in two doses (each 100 mg/kg of body weight), produced a good bactericidal activity (−0.47 Δlog(10) CFU/ml · h) which was comparable to that of levofloxacin (−0.49 Δlog(10) CFU/ml · h) against a penicillin-resistant pneumococcal strain WB4 in experimental meningitis. Cefotaxime com...

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Bibliographic Details

Published in:	Antimicrob Agents Chemother
Main Authors:	Kühn, F., Cottagnoud, M., Acosta, F., Flatz, L., Entenza, J., Cottagnoud, P.
Format:	Artigo
Language:	Inglês
Published:	American Society for Microbiology (ASM) 2003
Subjects:	Experimental Therapeutics
Online Access:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC166100/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/12878509/ https://ncbi.nlm.nih.govhttps://doi.org/10.1128/AAC.47.8.2487-2491.2003
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