Gemifloxacin Is Efficacious against Penicillin-Resistant and Quinolone-Resistant Pneumococci in Experimental Meningitis

In experimental rabbit meningitis, gemifloxacin penetrated inflamed meninges well (22 to 33%) and produced excellent bactericidal activity (change in log(10) [Δlog(10)] CFU/ml/h, −0.68 ± 0.30 [mean and standard deviation]), even superior to that of the standard regimen of ceftriaxone plus vancomycin...

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Bibliografiske detaljer
Main Authors: Cottagnoud, Philippe, Acosta, Fernando, Cottagnoud, Marianne, Täuber, Martin G.
Format: Artigo
Sprog:Inglês
Udgivet: American Society for Microbiology 2002
Fag:
Experimental Therapeutics
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC127126/
https://ncbi.nlm.nih.gov/pubmed/11959614
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/AAC.46.5.1607-1609.2002
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