Cefotaxime Acts Synergistically with Levofloxacin in Experimental Meningitis Due to Penicillin-Resistant Pneumococci and Prevents Selection of Levofloxacin-Resistant Mutants In Vitro

Cefotaxime, given in two doses (each 100 mg/kg of body weight), produced a good bactericidal activity (−0.47 Δlog(10) CFU/ml · h) which was comparable to that of levofloxacin (−0.49 Δlog(10) CFU/ml · h) against a penicillin-resistant pneumococcal strain WB4 in experimental meningitis. Cefotaxime com...

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Autors principals: Kühn, F., Cottagnoud, M., Acosta, F., Flatz, L., Entenza, J., Cottagnoud, P.
Format: Artigo
Idioma:Inglês
Publicat: American Society for Microbiology 2003
Matèries:
Experimental Therapeutics
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC166100/
https://ncbi.nlm.nih.gov/pubmed/12878509
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/AAC.47.8.2487-2491.2003
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