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The C Terminus of YopT Is Crucial for Activity and the N Terminus Is Crucial for Substrate Binding

Recently, it was shown that Yersinia outer protein T (YopT) belongs to a new family of cysteine proteases containing invariant C, H, and D residues that are crucial for its activity. YopT cleaves RhoA, Rac, and Cdc42 at their C termini, thereby releasing them from the membrane. Moreover, YopT inhibi...

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Udgivet i:Infect Immun
Principais autores: Sorg, Isabel, Hoffmann, Claudia, Dumbach, Juergen, Aktories, Klaus, Schmidt, Gudula
Format: Artigo
Sprog:Inglês
Udgivet: American Society for Microbiology (ASM) 2003
Fag:
Molecular Pathogenesis
Online adgang:https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC166019/
https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/12874342/
https://ncbi.nlm.nih.govhttps://doi.org/10.1128/IAI.71.8.4623-4632.2003
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