Lysine and Polyamines Are Substrates for Transglutamination of Rho by the Bordetella Dermonecrotic Toxin

Bordetella dermonecrotic toxin (DNT) catalyzes the transglutamination of glutamine-63/61 of Rho GTPases, thereby constitutively activating Rho proteins. Here we identified second substrates for transglutamination of RhoA by DNT. The enzymatically active fragment of DNT (residues 1136 to 1451, ΔDNT)...

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Bibliografiske detaljer
Main Authors: Schmidt, Gudula, Goehring, Udo-Michael, Schirmer, Joerg, Uttenweiler-Joseph, Sandrine, Wilm, Matthias, Lohmann, Mark, Giese, Arnd, Schmalzing, Guenther, Aktories, Klaus
Format: Artigo
Sprog:Inglês
Udgivet: American Society for Microbiology 2001
Fag:
Molecular Pathogenesis
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC98860/
https://ncbi.nlm.nih.gov/pubmed/11705946
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/IAI.69.12.7663-7670.2001
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