Toll-Like Receptor 2- and 6-Mediated Stimulation by Macrophage-Activating Lipopeptide 2 Induces Lipopolysaccharide (LPS) Cross Tolerance in Mice, Which Results in Protection from Tumor Necrosis Factor Alpha but in Only Partial Protection from Lethal LPS Doses

Patients or experimental animals previously exposed to lipopolysaccharide (LPS) become tolerant to further LPS challenge. We investigated the potential of the macrophage-activating lipopeptide 2 (MALP-2) to induce in vivo cross tolerance to tumor necrosis factor alpha (TNF-α) and LPS. MALP-2-induced...

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Detalhes bibliográficos
Main Authors: Deiters, Ursula, Gumenscheimer, Marina, Galanos, Chris, Mühlradt, Peter F.
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Microbiology 2003
Assuntos:
Host Response and Inflammation
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC166003/
https://ncbi.nlm.nih.gov/pubmed/12874325
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/IAI.71.8.4456-4462.2003
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