Toll-Like Receptor 2- and 6-Mediated Stimulation by Macrophage-Activating Lipopeptide 2 Induces Lipopolysaccharide (LPS) Cross Tolerance in Mice, Which Results in Protection from Tumor Necrosis Factor Alpha but in Only Partial Protection from Lethal LPS Doses

Patients or experimental animals previously exposed to lipopolysaccharide (LPS) become tolerant to further LPS challenge. We investigated the potential of the macrophage-activating lipopeptide 2 (MALP-2) to induce in vivo cross tolerance to tumor necrosis factor alpha (TNF-α) and LPS. MALP-2-induced...

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Bibliographic Details
Main Authors: Deiters, Ursula, Gumenscheimer, Marina, Galanos, Chris, Mühlradt, Peter F.
Format: Artigo
Language:Inglês
Published: American Society for Microbiology 2003
Subjects:
Host Response and Inflammation
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC166003/
https://ncbi.nlm.nih.gov/pubmed/12874325
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/IAI.71.8.4456-4462.2003
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