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Mechanism of Fluconazole Resistance in Candida albicans Biofilms: Phase-Specific Role of Efflux Pumps and Membrane Sterols

Candida albicans biofilms are formed through three distinct developmental phases and are associated with high fluconazole (FLU) resistance. In the present study, we used a set of isogenic Candida strains lacking one or more of the drug efflux pumps Cdr1p, Cdr2p, and Mdr1p to determine their role in...

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Main Authors: Mukherjee, Pranab K., Chandra, Jyotsna, Kuhn, Duncan M., Ghannoum, Mahmoud A.
Formato: Artigo
Idioma:Inglês
Publicado: American Society for Microbiology 2003
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Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC165995/
https://ncbi.nlm.nih.gov/pubmed/12874310
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/IAI.71.8.4333-4340.2003
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