Mechanism of Fluconazole Resistance in Candida albicans Biofilms: Phase-Specific Role of Efflux Pumps and Membrane Sterols

Candida albicans biofilms are formed through three distinct developmental phases and are associated with high fluconazole (FLU) resistance. In the present study, we used a set of isogenic Candida strains lacking one or more of the drug efflux pumps Cdr1p, Cdr2p, and Mdr1p to determine their role in...

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Detalhes bibliográficos

Publicado no:	Infect Immun
Principais autores:	Mukherjee, Pranab K., Chandra, Jyotsna, Kuhn, Duncan M., Ghannoum, Mahmoud A.
Formato:	Artigo
Idioma:	Inglês
Publicado em:	American Society for Microbiology (ASM) 2003
Assuntos:	Fungal and Parasitic Infections
Acesso em linha:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC165995/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/12874310/ https://ncbi.nlm.nih.govhttps://doi.org/10.1128/IAI.71.8.4333-4340.2003
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