Ca(2+)/calmodulin-dependent protein kinase II regulates cardiac Na(+) channels

In heart failure (HF), Ca(2+)/calmodulin kinase II (CaMKII) expression is increased. Altered Na(+) channel gating is linked to and may promote ventricular tachyarrhythmias (VTs) in HF. Calmodulin regulates Na(+) channel gating, in part perhaps via CaMKII. We investigated effects of adenovirus-mediat...

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Autori principali: Wagner, Stefan, Dybkova, Nataliya, Rasenack, Eva C.L., Jacobshagen, Claudius, Fabritz, Larissa, Kirchhof, Paulus, Maier, Sebastian K.G., Zhang, Tong, Hasenfuss, Gerd, Brown, Joan Heller, Bers, Donald M., Maier, Lars S.
Natura: Artigo
Lingua:Inglês
Pubblicazione: American Society for Clinical Investigation 2006
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Research Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC1654201/
https://ncbi.nlm.nih.gov/pubmed/17124532
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1172/JCI26620
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