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Episomal Persistence of Recombinant Adenoviral Vector Genomes during the Cell Cycle In Vivo

Previously we showed that recombinant adenoviral helper-dependent (HD) vectors result in long-term transgene expression levels in vivo which slowly declined by 95% over a period of 1 year. In this study, we further establish that this was not predominantly immune mediated. To determine if cell turno...

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Detalhes bibliográficos
Main Authors: Ehrhardt, Anja, Xu, Hui, Kay, Mark A.
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Microbiology 2003
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC164819/
https://ncbi.nlm.nih.gov/pubmed/12805471
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/JVI.77.13.7689-7695.2003
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