Viral Escape from Dominant Simian Immunodeficiency Virus Epitope-Specific Cytotoxic T Lymphocytes in DNA-Vaccinated Rhesus Monkeys

Virus-specific cytotoxic T lymphocytes (CTL) are critical for control of human immunodeficiency virus type 1 replication. However, viral escape from CTL recognition can undermine this immune control. Here we demonstrate the high frequency and pattern of viral escape from dominant epitope-specific CT...

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Autors principals: Barouch, Dan H., Kunstman, Jennifer, Glowczwskie, Jennifer, Kunstman, Kevin J., Egan, Michael A., Peyerl, Fred W., Santra, Sampa, Kuroda, Marcelo J., Schmitz, Jörn E., Beaudry, Kristin, Krivulka, Georgia R., Lifton, Michelle A., Gorgone, Darci A., Wolinsky, Steven M., Letvin, Norman L.
Format: Artigo
Idioma:Inglês
Publicat: American Society for Microbiology 2003
Matèries:
Vaccines and Antiviral Agents
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC164797/
https://ncbi.nlm.nih.gov/pubmed/12805435
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/JVI.77.13.7367-7375.2003
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