Human Gene Targeting by Adeno-Associated Virus Vectors Is Enhanced by DNA Double-Strand Breaks

The use of adeno-associated virus (AAV) to package gene-targeting vectors as single-stranded linear molecules has led to significant improvements in mammalian gene-targeting frequencies. However, the molecular basis for the high targeting frequencies obtained is poorly understood, and there could be...

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Pubblicato in:	Mol Cell Biol
Autori principali:	Miller, Daniel G., Petek, Lisa M., Russell, David W.
Natura:	Artigo
Lingua:	Inglês
Pubblicazione:	Taylor & Francis 2003
Soggetti:	DNA Dynamics and Chromosome Structure
Accesso online:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC164770/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/12724413/ https://ncbi.nlm.nih.govhttps://doi.org/10.1128/MCB.23.10.3550-3557.2003
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