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Human Gene Targeting by Adeno-Associated Virus Vectors Is Enhanced by DNA Double-Strand Breaks

The use of adeno-associated virus (AAV) to package gene-targeting vectors as single-stranded linear molecules has led to significant improvements in mammalian gene-targeting frequencies. However, the molecular basis for the high targeting frequencies obtained is poorly understood, and there could be...

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Détails bibliographiques
Auteurs principaux: Miller, Daniel G., Petek, Lisa M., Russell, David W.
Format: Artigo
Langue:Inglês
Publié: American Society for Microbiology 2003
Sujets:
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC164770/
https://ncbi.nlm.nih.gov/pubmed/12724413
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/MCB.23.10.3550-3557.2003
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