Oncogenic potential of TASK3 (Kcnk9) depends on K(+) channel function

TASK3 gene (Kcnk9) is amplified and overexpressed in several types of human carcinomas. In this report, we demonstrate that a point mutation (G95E) within the consensus K(+) filter of TASK3 not only abolished TASK3 potassium channel activity but also abrogated its oncogenic functions, including prol...

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Wedi'i Gadw mewn:
Manylion Llyfryddiaeth
Prif Awduron: Pei, Lin, Wiser, Ofer, Slavin, Anthony, Mu, David, Powers, Scott, Jan, Lily Yeh, Hoey, Timothy
Fformat: Artigo
Iaith:Inglês
Cyhoeddwyd: National Academy of Sciences 2003
Pynciau:
Biological Sciences
Mynediad Ar-lein:https://ncbi.nlm.nih.gov/pmc/articles/PMC164668/
https://ncbi.nlm.nih.gov/pubmed/12782791
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1232448100
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