Oncogenic potential of TASK3 (Kcnk9) depends on K(+) channel function
TASK3 gene (Kcnk9) is amplified and overexpressed in several types of human carcinomas. In this report, we demonstrate that a point mutation (G95E) within the consensus K(+) filter of TASK3 not only abolished TASK3 potassium channel activity but also abrogated its oncogenic functions, including prol...
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| Pubblicato in: | Proc Natl Acad Sci U S A |
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| Autori principali: | , , , , , , |
| Natura: | Artigo |
| Lingua: | Inglês |
| Pubblicazione: |
National Academy of Sciences
2003
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| Soggetti: | |
| Accesso online: | https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC164668/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/12782791/ https://ncbi.nlm.nih.govhttps://doi.org/10.1073/pnas.1232448100 |
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