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The Notch ligand Delta1 is sequentially cleaved by an ADAM protease and γ-secretase
Notch signaling is involved in numerous cell fate decisions in invertebrates and vertebrates. The Notch receptor is a type I transmembrane (TM) protein that undergoes two proteolytic steps after ligand binding, first by an ADAM (a distintegrin and metalloprotease) in the extracellular region, follow...
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| Autori principali: | , , , , , , |
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| Natura: | Artigo |
| Lingua: | Inglês |
| Pubblicazione: |
National Academy of Sciences
2003
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| Soggetti: | |
| Accesso online: | https://ncbi.nlm.nih.gov/pmc/articles/PMC164639/ https://ncbi.nlm.nih.gov/pubmed/12794186 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1230693100 |
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