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TSG101 interaction with HRS mediates endosomal trafficking and receptor down-regulation

Down-regulation of mitogenic signaling in mammalian cells relies in part on endosomal trafficking of activated receptors into lysosomes, where the receptors are degraded. These events are mediated by ubiquitination of the endosomal cargo and its consequent sorting into multivesicular bodies that for...

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Autori principali: Lu, Quan, Hope, Lila Weiqiao, Brasch, Michael, Reinhard, Christoph, Cohen, Stanley N.
Natura: Artigo
Lingua:Inglês
Pubblicazione: National Academy of Sciences 2003
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Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC164637/
https://ncbi.nlm.nih.gov/pubmed/12802020
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.0932599100
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