In vitro activities of the biguanide PS-15 and its metabolite, WR99210, against cycloguanil-resistant Plasmodium falciparum isolates from Thailand.

The in vitro activities of the new biguanide PS-15 and its putative active metabolite, WR99210, were determined against seven different isolates or clones of Plasmodium falciparum. The mean 50% inhibitory concentrations of PS-15 and WR99210 were 1,015 and 0.06 ng/ml, respectively. WR99210 was up to...

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Detalhes bibliográficos

Publicado no:	Antimicrob Agents Chemother
Principais autores:	Edstein, M D, Bahr, S, Kotecka, B, Shanks, G D, Rieckmann, K H
Formato:	Artigo
Idioma:	Inglês
Publicado em:	American Society for Microbiology (ASM) 1997
Assuntos:	Research Article
Acesso em linha:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC164114/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/9333069/ https://ncbi.nlm.nih.govhttps://doi.org/10.1128/aac.41.10.2300
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