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Modeling CTLA4-linked autoimmunity with RNA interference in mice

The CTLA4 gene is important for T lymphocyte-mediated immunoregulation and has been associated with several autoimmune diseases, in particular, type 1 diabetes. To model the impact of natural genetic variants of CTLA4, we constructed RNA interference (RNAi) “knockdown” mice through lentiviral transg...

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Bibliografski detalji
Glavni autori: Chen, Zhibin, Stockton, John, Mathis, Diane, Benoist, Christophe
Format: Artigo
Jezik:Inglês
Izdano: National Academy of Sciences 2006
Teme:
Online pristup:https://ncbi.nlm.nih.gov/pmc/articles/PMC1637594/
https://ncbi.nlm.nih.gov/pubmed/17060611
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.0607854103
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