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Modeling CTLA4-linked autoimmunity with RNA interference in mice
The CTLA4 gene is important for T lymphocyte-mediated immunoregulation and has been associated with several autoimmune diseases, in particular, type 1 diabetes. To model the impact of natural genetic variants of CTLA4, we constructed RNA interference (RNAi) “knockdown” mice through lentiviral transg...
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| Auteurs principaux: | , , , |
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| Format: | Artigo |
| Langue: | Inglês |
| Publié: |
National Academy of Sciences
2006
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| Sujets: | |
| Accès en ligne: | https://ncbi.nlm.nih.gov/pmc/articles/PMC1637594/ https://ncbi.nlm.nih.gov/pubmed/17060611 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.0607854103 |
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