General structural motifs of amyloid protofilaments

Human CA150, a transcriptional activator, binds to and is co-deposited with huntingtin during Huntington's disease. The second WW domain of CA150 is a three-stranded β-sheet that folds in vitro in microseconds and forms amyloid fibers under physiological conditions. We found from exhaustive ala...

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Bibliografiske detaljer
Main Authors: Ferguson, Neil, Becker, Johanna, Tidow, Henning, Tremmel, Sandra, Sharpe, Timothy D., Krause, Gerd, Flinders, Jeremy, Petrovich, Miriana, Berriman, John, Oschkinat, Hartmut, Fersht, Alan R.
Format: Artigo
Sprog:Inglês
Udgivet: National Academy of Sciences 2006
Fag:
Biological Sciences
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC1637568/
https://ncbi.nlm.nih.gov/pubmed/17060612
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.0607815103
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