Smoothened Signal Transduction Is Promoted by G Protein-Coupled Receptor Kinase 2

Deregulation of the Sonic hedgehog pathway has been implicated in an increasing number of human cancers. In this pathway, the seven-transmembrane (7TM) signaling protein Smoothened regulates cellular proliferation and differentiation through activation of the transcription factor Gli. The activity o...

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Main Authors: Meloni, Alison R., Fralish, Gregory B., Kelly, Patrick, Salahpour, Ali, Chen, James K., Wechsler-Reya, Robert J., Lefkowitz, Robert J., Caron, Marc G.
Format: Artigo
Jezik:Inglês
Izdano: American Society for Microbiology 2006
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Articles
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC1636865/
https://ncbi.nlm.nih.gov/pubmed/16908539
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/MCB.00546-06
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