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Smoothened Signal Transduction Is Promoted by G Protein-Coupled Receptor Kinase 2
Deregulation of the Sonic hedgehog pathway has been implicated in an increasing number of human cancers. In this pathway, the seven-transmembrane (7TM) signaling protein Smoothened regulates cellular proliferation and differentiation through activation of the transcription factor Gli. The activity o...
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| Main Authors: | , , , , , , , |
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| Format: | Artigo |
| Sprog: | Inglês |
| Udgivet: |
American Society for Microbiology
2006
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| Fag: | |
| Online adgang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC1636865/ https://ncbi.nlm.nih.gov/pubmed/16908539 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/MCB.00546-06 |
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