Rapid Loss of Intestinal Crypts upon Conditional Deletion of the Wnt/Tcf-4 Target Gene c-Myc

Inhibition of the mutationally activated Wnt cascade in colorectal cancer cell lines induces a rapid G(1) arrest and subsequent differentiation. This arrest can be overcome by maintaining expression of a single Tcf4 target gene, the proto-oncogene c-Myc. Since colorectal cancer cells share many mole...

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Hauptverfasser: Muncan, Vanesa, Sansom, Owen J., Tertoolen, Leon, Phesse, Toby J., Begthel, Harry, Sancho, Elena, Cole, Alicia M., Gregorieff, Alex, de Alboran, Ignacio Moreno, Clevers, Hans, Clarke, Alan R.
Format: Artigo
Sprache:Inglês
Veröffentlicht: American Society for Microbiology 2006
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Articles
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC1636776/
https://ncbi.nlm.nih.gov/pubmed/16954380
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/MCB.00821-06
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