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Notch1 Contributes to Mouse T-Cell Leukemia by Directly Inducing the Expression of c-myc
Recent work with mouse models and human leukemic samples has shown that gain-of-function mutation(s) in Notch1 is a common genetic event in T-cell acute lymphoblastic leukemia (T-ALL). The Notch1 receptor signals through a γ-secretase-dependent process that releases intracellular Notch1 from the mem...
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| Autors principals: | , , , , , , , , , |
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| Format: | Artigo |
| Idioma: | Inglês |
| Publicat: |
American Society for Microbiology
2006
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| Matèries: | |
| Accés en línia: | https://ncbi.nlm.nih.gov/pmc/articles/PMC1636748/ https://ncbi.nlm.nih.gov/pubmed/16954387 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/MCB.01091-06 |
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