Notch1 Contributes to Mouse T-Cell Leukemia by Directly Inducing the Expression of c-myc

Recent work with mouse models and human leukemic samples has shown that gain-of-function mutation(s) in Notch1 is a common genetic event in T-cell acute lymphoblastic leukemia (T-ALL). The Notch1 receptor signals through a γ-secretase-dependent process that releases intracellular Notch1 from the mem...

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Main Authors: Sharma, Vishva Mitra, Calvo, Jennifer A., Draheim, Kyle M., Cunningham, Leslie A., Hermance, Nicole, Beverly, Levi, Krishnamoorthy, Veena, Bhasin, Manoj, Capobianco, Anthony J., Kelliher, Michelle A.
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Microbiology 2006
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Articles
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC1636748/
https://ncbi.nlm.nih.gov/pubmed/16954387
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/MCB.01091-06
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