Cdx4 dysregulates Hox gene expression and generates acute myeloid leukemia alone and in cooperation with Meis1a in a murine model

HOX genes have emerged as critical effectors of leukemogenesis, but the mechanisms that regulate their expression in leukemia are not well understood. Recent data suggest that the caudal homeobox transcription factors CDX1, CDX2, and CDX4, developmental regulators of HOX gene expression, may contrib...

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Main Authors: Bansal, Dimple, Scholl, Claudia, Fröhling, Stefan, McDowell, Elizabeth, Lee, Benjamin H., Döhner, Konstanze, Ernst, Patricia, Davidson, Alan J., Daley, George Q., Zon, Leonard I., Gilliland, D. Gary, Huntly, Brian J. P.
Format: Artigo
Jezik:Inglês
Izdano: National Academy of Sciences 2006
Teme:
Biological Sciences
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC1636555/
https://ncbi.nlm.nih.gov/pubmed/17068127
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.0604579103
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