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Matrix-specific Suppression of Integrin Activation in Shear Stress Signaling

Atherosclerotic plaque develops at sites of disturbed flow. We previously showed that flow activates endothelial cell integrins, which then bind to the subendothelial extracellular matrix (ECM), and, in cells on fibronectin or fibrinogen, trigger nuclear factor-κB activation. Additionally, fibronect...

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Hlavní autoři: Orr, A. Wayne, Ginsberg, Mark H., Shattil, Sanford J., Deckmyn, Hans, Schwartz, Martin A.
Médium: Artigo
Jazyk:Inglês
Vydáno: The American Society for Cell Biology 2006
Témata:
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC1635406/
https://ncbi.nlm.nih.gov/pubmed/16928957
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1091/mbc.E06-04-0289
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