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Chain-Terminating Dinucleoside Tetraphosphates Are Substrates for DNA Polymerization by Human Immunodeficiency Virus Type 1 Reverse Transcriptase with Increased Activity against Thymidine Analogue-Resistant Mutants

Nucleoside reverse transcriptase inhibitors are an important class of drugs for treatment of human immunodeficiency virus type 1 (HIV-1) infection. Resistance to these drugs is often the result of mutations that increase the transfer of chain-terminating nucleotides from blocked DNA termini to a nuc...

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Bibliografiske detaljer
Main Authors: Meyer, Peter R., Smith, Anthony J., Matsuura, Suzanne E., Scott, Walter A.
Format: Artigo
Sprog:Inglês
Udgivet: American Society for Microbiology 2006
Fag:
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC1635194/
https://ncbi.nlm.nih.gov/pubmed/16940076
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/AAC.00537-06
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