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23S rRNA 2058A→G Alteration Mediates Ketolide Resistance in Combination with Deletion in L22
Resistance to macrolides and ketolides occurs mainly via alterations in RNA moieties of the drug-binding site. Using an A2058G mutant of Mycobacterium smegmatis, additional telithromycin resistance was acquired via deletion of 15 residues from protein L22. Molecular modeling, based on the crystal st...
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| Main Authors: | , , , , |
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| Format: | Artigo |
| Sprog: | Inglês |
| Udgivet: |
American Society for Microbiology
2006
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| Fag: | |
| Online adgang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC1635173/ https://ncbi.nlm.nih.gov/pubmed/16923950 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/AAC.00767-06 |
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