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Cell-free formation of misfolded prion protein with authentic prion infectivity
Prion propagation has been modeled in vitro; however, the low infectious titer of PrP(Sc) thus generated has cast doubt on the “protein-only” hypothesis. Here we show that prion delivery on suitable nitrocellulose carrier particles abrogates the apparent dissociation of PrP(Sc) and infectivity. Misf...
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| Hlavní autoři: | , , , , , , |
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| Médium: | Artigo |
| Jazyk: | Inglês |
| Vydáno: |
National Academy of Sciences
2006
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| Témata: | |
| On-line přístup: | https://ncbi.nlm.nih.gov/pmc/articles/PMC1635086/ https://ncbi.nlm.nih.gov/pubmed/17030802 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.0605608103 |
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