Design of Homogeneous, MonoPEGylated Erythropoietin Analogs With Preserved In Vitro Bioactivity

OBJECTIVE: Erythropoietin (Epo) bioactivity is significantly reduced by modification of lysine residues with amine-reactive reagents, which are the most commonly used reagents for attaching polyethylene glycols (PEGs) to proteins to improve protein half-life in vivo. The aims of this study were to d...

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Main Authors: Long, Dana L., Doherty, Daniel H., Eisenberg, Stephen P., Smith, Darin J., Rosendahl, Mary S., Christensen, Kurt R., Edwards, Dean P., Chlipala, Elizabeth A., Cox, George N.
Format: Artigo
Sprog:Inglês
Udgivet: 2006
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Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC1634893/
https://ncbi.nlm.nih.gov/pubmed/16728273
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.exphem.2006.02.011
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