Site-Specific PEGylation Enhances the Pharmacokinetic Properties and Antitumor Activity of Interferon Beta-1b

Interferon beta (IFN-β) is widely used to ameliorate disease progression in patients with Multiple Sclerosis. IFN-β has a short half-life in humans, necessitating frequent administration for optimum effectiveness. Covalent modification of IFN-β with polyethylene glycol (PEG) improves the pharmacokin...

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Bibliographic Details
Main Authors: Lee, Ji I., Eisenberg, Stephen P., Rosendahl, Mary S., Chlipala, Elizabeth A., Brown, Jacquelyn D., Doherty, Daniel H., Cox, George N.
Format: Artigo
Language:Inglês
Published: Mary Ann Liebert, Inc. 2013
Subjects:
Research Reports
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC3868373/
https://ncbi.nlm.nih.gov/pubmed/23962003
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1089/jir.2012.0148
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