Antimalarial effects of vinyl sulfone cysteine proteinase inhibitors.

We evaluated the antimalarial effects of vinyl sulfone cysteine proteinase inhibitors. A number of vinyl sulfones strongly inhibited falcipain, a Plasmodium falciparum cysteine proteinase that is a critical hemoglobinase. In studies of cultured parasites, nanomolar concentrations of three vinyl sulf...

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Dades bibliogràfiques

Publicat a:	Antimicrob Agents Chemother
Autors principals:	Rosenthal, P J, Olson, J E, Lee, G K, Palmer, J T, Klaus, J L, Rasnick, D
Format:	Artigo
Idioma:	Inglês
Publicat:	American Society for Microbiology (ASM) 1996
Matèries:	Research Article
Accés en línia:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC163380/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/8807047/ https://ncbi.nlm.nih.govhttps://doi.org/10.1128/aac.40.7.1600
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