In Vitro and In Vivo Synergy of Fosmidomycin, a Novel Antimalarial Drug, with Clindamycin

Fosmidomycin acts through inhibition of 1-deoxy-d-xylulose 5-phosphate (DOXP) reductoisomerase, a key enzyme of the nonmevalonate pathway of isoprenoid biosynthesis. It possesses potent antimalarial activity in vitro and in murine malaria. In a recent clinical study, fosmidomycin was effective and w...

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Bibliographic Details
Main Authors: Wiesner, Jochen, Henschker, Dajana, Hutchinson, David B., Beck, Ewald, Jomaa, Hassan
Format: Artigo
Language:Inglês
Published: American Society for Microbiology 2002
Subjects:
Experimental Therapeutics
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC127394/
https://ncbi.nlm.nih.gov/pubmed/12183243
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/AAC.46.9.2889-2894.2002
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