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How effective is KRM-1648 in treatment of disseminated Mycobacterium avium complex infections in beige mice?

Although the MICs of 3'-hydroxy-5'-(4-isobutyl-1-piperazinyl)benzoxazinorifamycin, or KRM-1648 (KRM), for Mycobacterium avium complex (MAC) were significantly lower than those of other drugs, its in vivo activity was very weak. Beginning 28 days after inoculation, beige mice that had been infected i...

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Bibliographic Details
Published in:Antimicrob Agents Chemother
Main Authors: Ji, B, Lounis, N, Truffot-Pernot, C, Grosset, J
Format: Artigo
Language:Inglês
Published: American Society for Microbiology (ASM) 1996
Subjects:
Online Access:https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC163130/
https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/8834894/
https://ncbi.nlm.nih.govhttps://doi.org/10.1128/aac.40.2.437
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