Inhibition of hepatitis B virus by a novel L-nucleoside, 2'-fluoro-5-methyl-beta-L-arabinofuranosyl uracil.

2'-Fluoro-5-methyl-beta-L-arabinofuranosyl uracil (L-FMAU) was discovered to have potent antiviral activity against hepatitis B virus (HBV). L-FMAU was more potent than its D-enantiomer and produced dose-dependent inhibition of the viral DNA replication in 2.2.15 cells (human HepG2 cells with the HB...

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Publicado en:	Antimicrob Agents Chemother
Autores principales:	Balakrishna Pai, S, Liu, S H, Zhu, Y L, Chu, C K, Cheng, Y C
Formato:	Artigo
Lenguaje:	Inglês
Publicado:	American Society for Microbiology (ASM) 1996
Materias:	Research Article
Acceso en línea:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC163120/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/8834884/ https://ncbi.nlm.nih.govhttps://doi.org/10.1128/aac.40.2.380
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