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Inhibition of hepatitis B virus by a novel L-nucleoside, 2'-fluoro-5-methyl-beta-L-arabinofuranosyl uracil.

2'-Fluoro-5-methyl-beta-L-arabinofuranosyl uracil (L-FMAU) was discovered to have potent antiviral activity against hepatitis B virus (HBV). L-FMAU was more potent than its D-enantiomer and produced dose-dependent inhibition of the viral DNA replication in 2.2.15 cells (human HepG2 cells with the HB...

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Udgivet i:Antimicrob Agents Chemother
Principais autores: Balakrishna Pai, S, Liu, S H, Zhu, Y L, Chu, C K, Cheng, Y C
Format: Artigo
Sprog:Inglês
Udgivet: American Society for Microbiology (ASM) 1996
Fag:
Research Article
Online adgang:https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC163120/
https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/8834884/
https://ncbi.nlm.nih.govhttps://doi.org/10.1128/aac.40.2.380
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