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Antiretroviral activity and pharmacokinetics in mice of oral bis(pivaloyloxymethyl)-9-(2-phosphonylmethoxyethyl)adenine, the bis(pivaloyloxymethyl) ester prodrug of 9-(2-phosphonylmethoxyethyl)adenine.
Lipophilic ester prodrugs of 9-(2-phosphonylmethoxyethyl)adenine (PMEA), i.e., bis(pivaloyloxymethyl)-PMEA [bis(POM)-PMEA] and diphenyl-PMEA, have been synthesized in an attempt to increase the oral bioavailability of this broad-spectrum antiviral agent. The antiretroviral efficacy was determined in...
Shranjeno v:
Main Authors: | , , , |
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Format: | Artigo |
Jezik: | Inglês |
Izdano: |
1996
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Teme: | |
Online dostop: | https://ncbi.nlm.nih.gov/pmc/articles/PMC163050/ https://ncbi.nlm.nih.gov/pubmed/8787873 |
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