Antiretroviral Efficacy and Pharmacokinetics of Oral Bis(isopropyloxycarbonyloxymethyl)9-(2-Phosphonylmethoxypropyl)adenine in Mice

To overcome the low oral bioavailability of the highly potent and selective antiretroviral agent (R)-9-(2-phosphonylmethoxypropyl)adenine (PMPA), a new lipophilic ester derivative, i.e., the bis(isopropyloxycarbonyloxymethyl)-ester [bis(POC)-PMPA], was prepared. The usefulness of bis(POC)-PMPA as an...

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Detalhes bibliográficos
Main Authors: Naesens, Lieve, Bischofberger, Norbert, Augustijns, Patrick, Annaert, Pieter, Van den Mooter, Guy, Arimilli, Murty N., Kim, Choung U., De Clercq, Erik
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Microbiology 1998
Assuntos:
Pharmacology
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC105646/
https://ncbi.nlm.nih.gov/pubmed/9660984
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