Metabolism and in vitro antiretroviral activities of bis(pivaloyloxymethyl) prodrugs of acyclic nucleoside phosphonates.

Bis(pivaloyloxymethyl) [bis(pom)] derivatives of various acyclic nucleoside phosphonates--9-(2-phosphonylmethoxyethyl)adenine (PMEA), 9-(2-phosphonylmethoxypropyl)adenine (PMPA), and 9-(2-phosphonylmethoxypropyl)diaminopurine (PMPDAP)--were found to exhibit 9- to 23-fold greater antiviral activity t...

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Veröffentlicht in:	Antimicrob Agents Chemother
Hauptverfasser:	Srinivas, R V, Robbins, B L, Connelly, M C, Gong, Y F, Bischofberger, N, Fridland, A
Format:	Artigo
Sprache:	Inglês
Veröffentlicht:	American Society for Microbiology (ASM) 1993
Schlagworte:	Research Article
Online-Zugang:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC192261/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/8257154/ https://ncbi.nlm.nih.govhttps://doi.org/10.1128/aac.37.10.2247
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