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Deregulated expression of insulin-like growth factor 1 in prostate epithelium leads to neoplasia in transgenic mice

Transgenic mice expressing human insulin-like growth factor 1 (IGF-1) in basal epithelial cells of prostate have been characterized. Transgene expression led to activation of the IGF-1 receptor and spontaneous tumorigenesis in prostate epithelium. Hyperplasia was evident in these mice by 2–3 months...

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主要な著者: DiGiovanni, John, Kiguchi, Kaoru, Frijhoff, Anita, Wilker, Eric, Bol, David K., Beltrán, Linda, Moats, Samantha, Ramirez, Angel, Jorcano, José, Conti, Claudio
フォーマット: Artigo
言語:Inglês
出版事項: The National Academy of Sciences 2000
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オンライン・アクセス:https://ncbi.nlm.nih.gov/pmc/articles/PMC16261/
https://ncbi.nlm.nih.gov/pubmed/10737798
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